TELOMERE LENGTH IS NEGATIVELY ASSOCIATED WITH BMI, R WAVE IN AVL AND IL-6 LEVEL IN PATIENTS WITH NEW CASES OF HYPERTENSION

Abstract

Objective: The aim of the study was to investigate the association between lymphocyte telomere length and cardiovascular risk factors in patients with new cases of hypertension according to 10-years prospective study in urban randomised population. Design and method: In 2007/2008 10-years prospective study of 3500 persons living in a district of Vitebsk (Belarus) and selected by the random number method started (coverage of the survey was 97.9%). According to the results of first examination 2170 persons had normal blood pressure. 1862 of them were examined on the second stage of the study in 2012/2013 (coverage of the survey was 85,8%). 286 new cases of hypertension were revealed and they had significant positive relationship with the IV quartile of uric acid level (> = 339 mol/l), determined on the first stage of the study. A 10-years prospective analysis was provided in 2017/2018 and included 145 randomized subjects with hypertension diagnosed on the second stage of the study. Results: We examined 2170 persons with normal blood pressure in 2007/2008. On the second stage of the study 286 new cases of hypertension were diagnosed in these subjects (14,4% of men and 12,2% of women). According to multifactorial regression analysis of 145 randomized subjects of 286 new cases of hypertension, adjusted for age and sex, the IV quartile of uric acid level (339–527 mol/l), determined on the first stage of the study, was associated with the I quartile of telomere length in 10 years (df = 1; 2Wald = 4,5; p < 0,05). Cross-sectional analysis of these subjects showed that the level of telomere length had a significant negative association with BMI (=-0,19; p < 0,05), R wave in aVL (=-0,18; p < 0,05), IL-6 level (=-0,20; p < 0,05) in 2017/2018. Conclusions: Regardless of age and sex, telomere length has negative association with BMI, R wave in aVL and IL-6 level in patients with new cases of hypertension.