Abstract
Objective: To analyze the role of serum uric acid levels in development of hypertension in a large adult population using the data from Belarusian national representative survey. Design and method: A 5-year prospective analysis included 3500 individuals in a district of Vitebsk in 2007/2008 (coverage of the survey was 97.9%), 2010/2011 (coverage of the survey was 77.8%) and 2012/2013 (coverage of the survey was 84.3%). Hypertension was evaluated according to the WHO/ISH (1999). The survey included standard questionnaires for detection of cardiovascular risk factors, measurements of blood pressure, electrocardiography, serum uric acid and C-reactively protein, cholesterol data. Results: We examined 2170 persons with normal blood pressure and 1257 persons with hypertension. Men and women were similar of mean age. In 5 years 285 new cases of hypertension developed (16.4% of men and 13.6% of women). There was revealed significant positive association between IV quartiles of serum uric acid level (339–527 mmol/l) and the frequency of new cases of hypertension adjusted for age and sex (df = 1; X2Wald = 5,1; p < 0,05). According to multifactorial regression analysis high uric acid level (>338 mmol/l) (p < 0.001) the same as systolic blood level (> 120 mmHg) (p < 0.001), high body mass index level (>25.7 kg/m2) (p < 0.001), high level of the amount of ECG peaks (SV1 + RV5 − V6 > 25 mm) (p < 0.001), moderate increase in body mass index (23,7 kg/m2 < BMI < = 25,7 kg/m2) (p < 0.001), high level of heart rate (>70 beat/min) (p < 0.01), alcohol abuse (p < 0.01), family history of stroke (p < 0.05) are the most significant factors affecting the frequency of new cases of hypertension in the studied population. At the same time the level of serum uric acid was associated with male sex (p < 0,001). And there was no relation between serum uric acid and other risk factors. Conclusions: The serum uric acid level is an independent risk factor for development of hypertension in the Belarusian urban population associated with male sex.
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