Abstract
The incidence of the combination of pregnancy and hyperthyroidism is very low. Javert reports 18 cases of hyperthyroidism in 23,439 pregnancies (0.076 per cent), McLaughlin and McGoogan 19 cases in 6,112 (0.3 per cent). We have been able to find reports of less than 10 cases of hyperthyroidism in pregnancy treated with thiouracil—so far without any toxic effect on either mother or child. However, since the drug has caused a number of complications, we might anticipate the probability of toxicity in a certain percentage of mothers. Experimental studies of the effect of thiourea on pregnant rats indicate the possibility of damage to the offspring, with characteristic thyroid hyperplasia and retardation of development. For these reasons we have been hesitant about employing thiouracil in cases of hyperthyroidism complicated with pregnancy, and in all cases except the 1 here reported we have followed older measures of therapy as adapted to the individual.
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