Abstract
Titanium dioxide (TiO2) coatings are demanded in clinical applications due to their biocompatible, porosity, and semiconducting properties. Drug release studies take advantage of these unique aspects of TiO2 for painless injection for those who have to take medicine through the injection frequently. In this study, TiO2 was prepared via the sol-gel method with Titanium tetra isopropoxide (TTIP) precursor in alcohol solvent for pH 3, 4, and 5 values. The prepared solution was coated on stainless steel substrates and injectors via dip coating. Following these steps, samples were calcinated at various temperatures (100°C, 300°C, 500°C, 700°C). The structural, physical, and chemical composition, chemical bond, wettability, and drug-release properties of coated samples were researched. Contact angle values affirmed that high temperatures and ultraviolet (UV)-light irradiation made samples more hydrophilic (26°±5° at 700°C for pH 4). Procaine, a short-time period local anaesthetic, was chosen as a model drug. Increased calcination temperature and raised hydrophilicity led to improve the released drug amount. Drug release studies were carried out using Franz diffusion cells at 36.5°C. Samples at 500°C calcinated released the highest amount of drug (90%) for 45 sec injection time. This study shed light on how TiO2 coating can be successfully utilized for clinical applications in the future.
Published Version
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