Hybrids of imidazole with indoline derivatives: Microwave assisted synthesis, molecular docking studies, possible biological activities

Abstract

A new hybrids of imidazole with Indole derivative 1-methyl-3-((1-(2-methyl-1H-Imidazole.-1yl)-methyl)-1H-indol-5-yl)imino)indolin-2-one(3a-o) was prepared by microwave-assisted technique via alkylation and Schiff's and Mannich base mechanism. The chemical structures of the synthesized products were confirmed by IR, 1HNMR and Mass spectra. The in vitro anticancer activity was evaluated via MTT assay technique, as well as their anthelmintic activity by utilising Indian earth warms. Most of the compounds 1-methyl-3-((1-(2-methyl-1H-Imidazole-1yl)-methyl)-1H-indol-5-yl)imino)indolin-2-one demonstrated greater anthelmintic action than the other compounds. The compounds 1,5-dimethyl-3-((1-(2-methyl-1H-Imidazole-1-yl)-methyl)-1H-indol-5-yl)-imino)-indole-2-one and 1-benzyl-5--chloro-3-((1-((2-methyl-1H--imidazole-1-yl) methyl)-1H-indol-5-yl) imino)indolin-2-one exhibit good anticancer action. Lastly, whenever the interaction pattern and selectivity towards the EGFR activity site have been examined, the molecular docking experiments of novel indole derivatives demonstrated good alignment only with biological findings.