Abstract
Objective To uncover the effect of human chorionic gonadotrophin (hCG) on the invasion of choriocarcinoma cells.Methods The effect of hCG on the expression of matrix metalloproteinases (MMPs) in JEG\|3 choriocarcinoma cell line was investigated by applying the method of reverse transcription polymerase chain reaction (RT\|PCR). Results The results showed that, among the 18 types of MMPs only MMP\|8,\|10, \|12,\|19 were found to be expressed by JEG\|3 cells. After the incubation with 25 IU/ml hCG for 50hours, the expression of these 4 types of MMPs were all significantly reduced. Conclusion The invasiveness of JEG\|3 choriocarcinoma cell line was associated with the expression of MMP\|8, \|10, \|12, \|19, high levels of hCG could reduce the invasion of choriocarcinoma cells by inhibiting MMPs expression.
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