Abstract
Intrauterine insemination is a treatment used in couples with mild/moderate male factor, when female partner has at least one tube patent. Numerous studies have attempted to determine for many years which parameters are limiting to ensure pregnancy with this technique of assisted reproduction. This review focus on prognostic factor for a successful outcome, as semen quality, female etiology, synchronization with ovulation, assessment of follicle rupture, number of insemination per cycle and influence of uterine contractions. We conclude with this review that intrauterine insemination is a less invasive and expensive option than other [IVF], with acceptable results when adequately indicated.
Highlights
The use of Assisted Reproductive Technology [ART] is a highly successful methodology for the treatment of infertility
Double Intrauterine Insemination (IUI) is initially suggested to provide a higher number of inseminated motile spermatozoa, and this number is associated with clinical pregnancy rate, especially in couples with male factor problems
Zavos et al concluded in their metaanalysis, after analyzing these 5 Randomize Clinical Trial (RCT), no significant differences were found between the two groups, there was a trend towards double IUI cycles
Summary
The use of Assisted Reproductive Technology [ART] is a highly successful methodology for the treatment of infertility. Intrauterine Insemination [IUI] is considered the simplest and least invasive procedure with reasonable live birth rates and not needing expensive infrastructure [1]. Human intrauterine inseminations were first reported by Cohen in 1962 [3]. With regard to IUI-H, 176 512 cycles [+13 669] were reported by 23 countries—the main contributors being France, Italy and Spain. Among the countries reporting deliveries, the mean delivery rate per cycle was 8.9%, with a 9.3% of twin deliveries and a 0.5% of triplet deliveries. For IUI-D, 38 124 cycles were reported [+8889] by 20 countries, the main contributors being Denmark, France, Spain and the United Kingdom. The objective of this review is to attempt to clarify these questions in order to establish the optimal parameters to perform an intrauterine insemination. Progesterone administration is considered the gold standard
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