Abstract
The major goal of abuse-deterrent formulations is to help reduce and prevent harm associated with the misuse and abuse of prescription medications. Currently, only a handful of prescription opioid medications have utilized these technologies in both immediate and extended-release formulations. Additionally, an over-the counter cold medication (Zephrex-D®) has entered the market using an abuse-deterrent formulation that inhibits extraction of pseudoephedrine to prohibit illicit methamphetamine production. As these novel formulations move into clinical practice, ways of testing and proving their level of abuse resistance both in-vitro and in the real world has been a topic of great interest.
Highlights
The major goal of abuse-deterrent formulations is to help reduce and prevent harm associated with the misuse and abuse of prescription medications
An over-the counter cold medication (Zephrex-D®) has entered the market using an abuse-deterrent formulation that inhibits extraction of pseudoephedrine to prohibit illicit methamphetamine production. As these novel formulations move into clinical practice, ways of testing and proving their level of abuse resistance both in-vitro and in the real world has been a topic of great interest
This is similar to child-resistant closures used on bottles. Such closure systems are only required to keep 20% or less of children from gaining access to a bottle within 10 minutes. This means that if given ample time, and with continued persistence, an abuser can become successful at gaining access to potentially harmful drugs in tamper-resistant formulations
Summary
The major goal of abuse-deterrent formulations is to help reduce and prevent harm associated with the misuse and abuse of prescription medications.
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