Hongteng decoction combined with levofloxacin in chronic pelvic inflammatory disease

Abstract

Objective: To explore the clinical therapeutic effect of Hongteng decoction combined with levofloxacin on chronic pelvic inflammatory disease (CPID) patients and its effect on the expression of inflammatory factors. Methods: 72 patients with CPID who were diagnosed and treated in the Fourth Hospital of Shijiazhuang City from January 2020 to December 2020 were selected and randomly divided into observation group (n = 36) and control group (n = 36). The control group was treated with levofloxacin and the observation group was treated with Hongteng decoction retention enema on the basis of the control group. Both groups were treated continuously for 2 courses. The clinical therapeutic effects of the two groups were compared, and the changes of related inflammatory indexes such as interleukin-2 (IL-2), interleukin-10 (IL-10), C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) were compared between the two groups before and after treatment. The score of quality of life and the occurrence of adverse reactions before treatment were compared. Results: The total effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). The inflammatory indexes of IL-2, IL-10, CRP and TNF-α in 2 groups before treatment were compared, and there was no statistical significance (P>0.05). After treatment, the expression of IL-2 and IL-10 in the observation group was higher than that in the control group, and the expression of CRP and TNF-α was lower than that in the control group, with statistical significance (P<0.05). There were no significant differences in physical pain, life function, social function and mental health scores between the two groups before treatment (P>0.05). After treatment, scores of physical pain, life function, social function and mental health in the observation group were higher than those in the control group, and the differences were statistically significant (P<0.05). After treatment, there was no significant difference in the incidence of adverse reactions between the observation group and the control group (P>0.05). Conclusion: Hongteng decoction combined with levofloxacin has definite efficacy in the treatment of CPID, which can effectively improve the clinical symptoms of patients and inhibit inflammatory response, and is worthy of clinical promotion.