Histopathological Study of Endoscopic Biopsies

Choodamani Aryal,Kamana Subba,Mamta Lakhey,Pradeep Kumar Yadav,Prakash Kandel,Rupendra Thapa

doi:10.31729/jnma.2116

Abstract

Diseases of upper gastrointestinal tract are responsible for a great deal of morbidity and mortality. The histopathological study of endoscopic biopsies permits exact diagnosis for further management.The aim of this study is to ﬁnd out the histopathological pattern of endoscopic biopsy. A descriptive study was conducted in consecutive endoscopic gastric biopsies in a Hospital over a period of one year. The patient of all ages and both sexes who underwent gastric biopsy during the study period was included. Endoscopic biopsies were studied on patients of age ranging from 20 years female to 84 years male. The histopathology revealed non-neoplastic lesions 54 (67.5%) and neoplastic lesions 26 (32.5%). Most common non-neoplastic lesion noted was mild chronic gastritis 22(27.5%) followed by chronic active gastritis 15 (18.75%) while H. pylori was present in 13 (16.25%) and absent in 2 (2.5%). Mild chronic gastritis was the commonest lesion noted in non-neoplastic lesions and adenocarcinoma was the commonest neoplastic lesion in the endoscopic gastric biopsies.

Highlights

Diseases of upper gastrointestinal tract are responsible for a great deal of morbidity and mortality
The aim of this study is to find out the histopathological pattern of endoscopic biopsy
Biopsy sampling of the gastric mucosa at diagnostic endoscopy provides useful information which helps in the diagnosis of various lesions

Summary

Introduction

The histopathological study of endoscopic biopsies permits exact diagnosis for further management.The aim of this study is to find out the histopathological pattern of endoscopic biopsy. Diseases of upper gastrointestinal tract are responsible for a great deal of morbidity and mortality. The term gastritis should be reserved for histologically documented inflammation of the gastric mucosa. Gastritis is defined as inflammation of the gastric mucosa. Inflammation may be predominantly acute, with neutrophilic inflammation, or chronic, with lymphocytes and/or plasma cells predominating and associated intestinal metaplasia and atrophy.[1] Gastritis has been classified in several ways, which differ from one country to another, sometimes from one department to another and even within a single institution, depending upon the investigator concerned. In order to avoid confusion, Sydney system has been proposed for the microscopic reporting of gastritis.[2]

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