Abstract
Introduction: placenta is vital link between mother and fetus. The organ for pregnancy serves as exchange membrane and hormone synthesizing apparatus for both mother and fetus. All physiological processes occurring in fetus or mother are reflected on placenta. Pregnancy induced hypertension is such a co-morbid condition which affects mother and fetus as well as placenta. Aim and objective: To study the desired histomorphometrical parameters in control and experimental (PIH) group of placentae after staining with Hematoxylin & Eosin(H/E) and Masson’s trichrome to find out the statistical relevance of the comparative findings. Material and method: Forty (40) control and forty (40) experimental placentae (PIH) were collected and processed for routine histological techniques. Paraffin sections were stained with routine H/E and Masson’s trichrome stain. Light microscopy for histological and histomorphometrical study was performed to obtain volume proportion of fibrinoid degeneration and microscopic calcification. Observation: volume proportion of fibrinoid degeneration and microscopic calcification were significantly increased in PIH cases in comparison to control. Conclusion: Like other diseases the PIH also affects the structural and functional unit of placenta. The changes appear to be compensatory to hypoxia and altered metabolism in tissue space.
Highlights
Placenta is the organ belonging to the developing mammalian conceptus which is never incorporated in the body of foetus but it is vital to the well-being of the baby in the womb and it offers protective, nutritional, respiratory, synthetic and excretory functions
Preparation for examination of placenta: The intact sample of placenta was kept for one week in 10% formal saline for fixation and hardening so as to make it suitable for cutting into 2-3 cm pieces for further routine histological processing followed by section cutting, staining, microscopy and microphotography
Areas of fibrinoid degeneration: The eosinophilic homogeneous amorphous or fine lamellar or fibrillary or hyalinised substance seen in Hematoxylin and Eosin (H/E) stained sections around the villi, within the vilus, within the basal plate (Nitabuch’s stria, many times referred to as maternal floor infarct), adjoining intervillous space and chorionic plate (Langhans stria) or rarely adjoining intervillous space and basal plate (Rohr’s stria)
Summary
Placenta is the organ belonging to the developing mammalian conceptus which is never incorporated in the body of foetus but it is vital to the well-being of the baby in the womb and it offers protective, nutritional, respiratory, synthetic and excretory functions. It exists as a vital link between mother and developing fetus[1]. Trophoblasts are responsible for a successful outcome of pregnancy- a healthy baby and healthy mother, at the completion of intra-uterine life[2,3,4,5, 6].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
