Histological Changes of Liver and Lung Induced by Bisphenol a in Pregnant Mice

Abstract

The current study was conducted to investigate the tissue lesions induced by Bisphenol (BPA) in pregnant mice. The administration of BPA (450 mg/kg) begins from the seventh to the eighteenth day of pregnancy. The results showed behavioral changes that include increased activity and movement excessive, aggressive behavior and irritability for 15 minutes after the dose, sensitivity and itching in the ear area, and sleeping for several hours with decreased activity and loss of appetite, especially on the 17th and 18th days of pregnancy, bleeding and inflammation in the vaginal area was also observed on the 16th day of pregnancy. On the other hand, the results showed that the weights of pregnant mothers increased with the increase in BPA concentration compared to the control group. Histological changes in the fetus included congestion and swelling of sinusoids, necrosis, degeneration of hepatocytes, and infiltration of mono-nucleated cells. The lung showed destruction of bronchi, and thickening of inflamed cells. Alveolar walls were showed inflammatory cell infiltration and hemorrhage.