Highly water-soluble and liver targeting BODIPY polymeric dyes

Abstract

supramolecular assembly approach and applied on cotton cloth to assess the benefits to the skin of the wearer. After simply mixing an ethanol solution of Ve and poly(vinyl pyrrolidone) (PVP) and an aqueous solution of chitosan, a stable emulsion was obtained. The emulsion was comprised of ~400 nm nanocapsules as shown by laser scattering. After application on a cotton cloth by a common dip-pad process, the soft nanocapsules assembled into a continuous thin film containing Ve nano-droplets. The activity of Ve present on the cotton fabric was demonstrated by rapid fading of a pink ethanol solution of dichloroindophenol dropped onto the fabric. The Ve quantity present on the fabric was in-situ measured colorimetrically by a spectrometer, based on the specific absorption of Ve at 295 nm. The stability of Ve on the fabric was checked by washing according to the AATCC standard. It was shown that the coated film was stable over 20 washes due to the strong interaction between chitosan and cotton. The Ve intimate apparel was expected to transfer Ve to thewearers' skin by friction and pressure. This transfer mechanism was simulated by standard rubbing of the Ve fabric against a piece of sheep leather, using a crock meter CM-1 according to the AATCC standard. With a calorimetric measurement, vitamin E transfer to leather was confirmed. An in-vivo trial on volunteers' arms revealed that these fabrics have definitely improved their skin condition, such asmoisture, whiteness and elasticity, based on the monitoring with Multi Skin Test Center® MC 900 within a month. These results support the application of supramolecular nanocapsules in nutritional intimate apparels and medical cloths [2].