Abstract
The endosomal sorting complexes required for transport (ESCRTs) conduct membrane remodeling and scission throughout the cell, with the ESCRT-III complex polymerizing into spiraling, sometimes multi-component, filaments on membrane surfaces to form tight tubules or necks that can be cut. Recent cryo-EM has solved a normal-topology complex of two ESCRT-III components, CHMP1B and IST1, forming a double-layered helix that constricts model endosomal membranes into tubules with an inner membrane diameter of 4 nm—near the point of spontaneous scission.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
