Abstract
A high-performance liquid chromatographic method with electrochemical detection has been developed to measure norepinephrine (NE) and α-methylnorepinephrine (α-MeNE) in microdissected noradrenergic cell groups of the rabbit brain stem. The method is shown to be specific, accurate and precise and has a sensitivity of 0.5 pmol per sample. The method has been applied to the measurement of NE and α-MeNE levels in the A1, A2, A5, A6 and A7 noradrenergic cell groups after administration of the antihypertensive drug α-methyl-dopa (α-MD), so that the sites of action of α-MD within the central nervous system may be localised.
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