High intake of fruit and vegetables is related to low oxidative stress and inflammation in a group of patients with type 2 diabetes

Rikard Åsgård,Samar Basu,Bengt Vessby,Lilianne Abramsson-Zetterberg,Lennart Möller,Elisabet Rytter

doi:10.1080/17482970701737285

Rikard Åsgård, Samar Basu + Show 4 more

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https://doi.org/10.1080/17482970701737285

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Abstract

BackgroundPatients with type 2 diabetes have increased levels of oxidative stress and inflammation. A high fruit and vegetable intake may be beneficial.ObjectiveTo study whether fruit and vegetable intake and levels of plasma antioxidants relate to markers of oxidative stress and inflammation in a group of patients with type 2 diabetes. Further, to investigate whether plasma antioxidants are good biomarkers for intake of fruit and vegetables.DesignPatients with type 2 diabetes were studied. Their dietary intake and levels of plasma antioxidants, and markers of oxidative stress and inflammation were analysed.ResultsFruit and vegetable intake was inversely related to oxidative stress. Plasma carotenoids were negatively correlated with inflammation. The plasma levels of α-carotene and β-carotene showed strongly positive associations with fruit and vegetable intake.ConclusionsThe results suggest that fruit and vegetable intake may decrease oxidative stress and inflammation in this group of patients. An increased intake of fruit and vegetables can therefore be beneficial for patients with type 2 diabetes, since these patients are documented to have raised oxidative stress and inflammation. The study support the usefulness of plasma α-carotene and β-carotene as biomarkers for fruit and vegetable intake.

Highlights

It is well known that diet can affect the health status of patients with type 2 diabetes
The analyses show that fruit and vegetable intake were negatively correlated with DNA oxidation and lipid peroxidation (8-iso-PGF2a), whereas dietary vitamin C was inversely correlated with lipid peroxidation (8-isoPGF2a) (Table 6)
This study on 54 patients with type 2 diabetes with stable metabolic control investigated whether fruit and vegetable intake, dietary antioxidants or plasma antioxidants were correlated with markers of oxidative stress and/or inflammation

Summary

Introduction

It is well known that diet can affect the health status of patients with type 2 diabetes. Patients with type 2 diabetes have increased levels of oxidative stress and inflammation. Objective: To study whether fruit and vegetable intake and levels of plasma antioxidants relate to markers of oxidative stress and inflammation in a group of patients with type 2 diabetes. Design: Patients with type 2 diabetes were studied Their dietary intake and levels of plasma antioxidants, and markers of oxidative stress and inflammation were analysed. Conclusions: The results suggest that fruit and vegetable intake may decrease oxidative stress and inflammation in this group of patients. An increased intake of fruit and vegetables can be beneficial for patients with type 2 diabetes, since these patients are documented to have raised oxidative stress and inflammation. The study support the usefulness of plasma a-carotene and b-carotene as biomarkers for fruit and vegetable intake

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