Abstract
High density lipoprotein and kidney dysfunction among post kidney transplant patients
Highlights
Dyslipidemia is commonly found in patients after kidney transplantation and it is associated with cardiovascular complications
The present study showed that poorly controlled high-density lipoprotein (HDL) levels did not seem to predispose the transplanted kidney graft to dysfunction in our patients, in those whom we could not identify a clear reason for transplant dysfunction or failure
The study has importance from a public health prospective, as to whether intervention is needed on a large scale in this particular subset of patient with low or worsening HDL level post renal transplant
Summary
Dyslipidemia is commonly found in patients after kidney transplantation and it is associated with cardiovascular complications. Kidney transplant patients suffer high mortality due to cardiovascular diseases. There is a progressive rise in the number of kidney transplant patients world-wide and in Oman [1,2]. Patients with kidney transplantation are at increased risk of accelerated atherosclerosis and a marked increase in cardiovascular (CV) mortality [3]. Post-renal transplant (Tx) patients exhibit a high CV morbidity and mortality due to accumulation of CV risk factors such as oxidative stress, inflammation, hypertension, endothelial dysfunction, vascular calcification, medications, metabolic abnormalities and dyslipidemia [4]. Some of the transplant kidney dysfunctions and failures have causes that are identified, including infections, drugs, recurrence of original kidney disease [5]. Other transplant failures are multifactorial, and a specific cause cannot usually be identified [6]
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