Anti-glomerular basement membrane disease case series in Trinidad and Tobago

E Mohammed,A Ramrattan,Avc Rao,A Bissessar,S Giddings,P Poon-King,A Ramesar

doi:10.15761/nrd.1000179

Abstract

Anti-glomerular basement membrane disease case series in Trinidad and Tobago

Highlights

Goodpasture’s syndrome (GS) or Anti-glomerular basement membrane disease (Anti-GBM) is a rapidly progressive glomerulonephritis (RPGN) with or without pulmonary hemorrhage characterized as a type 2 hypersensitivity reaction against type 4 collagen in the basement membrane
This patient with acute kidney injury was diagnosed with a likely primary glomerulonephritis and she was commenced on acute hemodialysis
Patient was converted to Peritoneal Dialysis (PD) and anti-hypertensives changed to amlodipine, hydralazine and alpha-methyldopa

Summary

Introduction

Goodpasture’s syndrome (GS) or Anti-glomerular basement membrane disease (Anti-GBM) is a rapidly progressive glomerulonephritis (RPGN) with or without pulmonary hemorrhage characterized as a type 2 hypersensitivity reaction against type 4 collagen in the basement membrane. It presents more commonly in the white and Asian population and is exceedingly rare in the African population. Admitting Creatinine was 1.7 mg/dl and admitting Urinalysis showed 3+ blood and 1+ protein She was assessed as an acute pyelonephritis with microcytic anemia and acute kidney injury at the time of admission. Ds-DNA positive, anti-histone/SSB positive, Anti GBM antibodies: 423.67 (elevated)

Findings

Discussion

Conclusion