HIGH CAPACITY COUNTER CURRENT CHROMATOGRAPHY FOR THE ISOLATION OF ACTIVE INGREDIENTS FROM MEDICINAL PLANTS

Abstract

s. PHYTOPHARM 2012 M 60 Obzory po kliniceskoj farmacologii i lekarstvennoj terapii [Reviews of clinical pharmacology and drug therapy] ТОМ 10/2012/2 Schisandrols A and b, schisantherin A, schisandrins A and b were detected in Schisandra oil extract by hPTlC (fig. 1A). These lignans are considered to be the main active substances of Schizandra chinensis. lignans antioxidant activity plays a significant role in pharmacological activity of Schizandra drugs (3). We established that these lignans don’t have fRSA by dPPh. They don’t bleach background of the plate after dPPh solution derivatization (fig. 1b). fRSA of Schizandra oil extract depend on other components of the extract, but not lignans. Thus, Schizandra oil extract is a source not only of the well-known lignans, but of other active compounds with the fRSA. The fRSA of these substances causes of their pharmacological importance.