Herpes Simplex & Cytomegalo Viruses inflicted semen substantiates infertility among men.

Abstract

Infertility is a growing challenge worldwide that cause many affiliated socio-psychological problems in many cultures that carry a negative impact on many families. As a last resort, many physicians engage certain drugs to over stimulate the gonadotropins to hope for the production of healthy Sperms and Ovum to materialize the fertility. Also, Fertilization in Vitro is a growing solution for the rich but many patients are not able to afford. Over stimulation of the sperms or ovum does not constitute the chromosomal DNA/RNA to amicably contribute to the successful fertility, Normal fetal development, uneventful pregnancy and/ or normal delivery. Many countries have established the prominent link to the Cytomegaloviral and Herpes Simplex Virus to the infertility. We studied the prevalence and the role of herpes simplex virus (HSV), cytomegalovirus (CMV) in the semen of infertile men. Data was collected from sixty nine infertile men. Serum AntiHSV IgG & IgM, CMV IgG & IgM from the blood and the Real Time Polymerase chain reaction RT/ PCR test were performed on the semen to detect the presence of the HSV & CMV RNA’s in these infertile subjects. AntiCMV IgG was found in 44 (62.9%), CMV IgM in 4 (5.9%), HSV IgG in 22 (31.4%), HSV IgM in (0%) and PCR of CMV in 26 (37.1%), HSV PCR in 13 (18.8%). Overall, results revealed that the RT/ PCR of CMV were relatively more prevalent in the semen of infertile men as compared to the HSV IgG & IgM, CMV IgG & CMV IgM in the blood of infertile men.