Abstract
Herpes Simplex Virus (HSV) is a common pathogen that leads to lifelong latent infection and may be associated with transmission from mother to their fetus. A total of 191 blood samples of preg- nant women were collected to check the prevalence of Herpes Simplex Virus (HSV). It was ob- served that 124 (64.9%) and 04 (2.1%) samples were positive for HSV IgG and HSV IgM, respec- tively. Seropositivity of HSV IgG was the highest for third trimester and it was followed by second and first trimester; while it was the highest for first trimester for HSV IgM and it was followed by third and second trimester. Seroprevalence of HSV IgG and IgM was statistically insignificant (P > 0.05) according to gestation age. A significant correlation was observed between HSV IgG and age groups of pregnant women; while it was insignificant for HSV IgM. Seroprevalence of HSV IgG+ IgM- was 32 (53.3%), 61 (66.3%), and 27 (69.2%) for first, second and third trimester, respectively. Seroprevalence of HSV IgG+ IgM+ group was 02 (3.3%), 01 (1.1%) and 01 (2.6%) for first, second and third trimester, respectively. Seroprevalence of HSV IgG- IgM- group was 26 (43.3%), 30 (32.6%), and 11 (28.2%) for first, second and third trimester, respectively.
Highlights
Viral infections mainly rubella, cytomegalovirus and herpes simplex virus (HSV) account for major part of maternal infections causing unfavourable outcome of pregnancy [1]
A total of 124 (64.9%) and 04 (2.1%) out of 191 samples were positive for Herpes Simplex Virus (HSV) IgG and HSV IgM, respectively
The positivity for HSV IgG indicates past infection of HSV, and our findings are similar with the previous study [17]
Summary
Cytomegalovirus and herpes simplex virus (HSV) account for major part of maternal infections causing unfavourable outcome of pregnancy [1]. Primary infection of HSV acquired by women during pregnancy accounts for half of the morbidity and mortality among neonates; while the remaining half result from the reactivation of an old infection [3]. The virus can reside as life-long virus and remains latent until the opportunity for recurrence, genital herpes is generally a recurrent and incurable viral disease [1]. The majority of both primary and recurrent infections are asymptomatic diseases [8]; in symptomatic cases, lesions are very painful [9] and obviously affect the quality of the life in patients [10]. The objectives of the present experiment were to study seroprevalence of HSV (IgG and IgM antibodies) in pregnant women of gangetic plain regions of India and its correlation to gestation age and age groups
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