Abstract
28Jun 2017 HEPATOTOXICITY OF THE AQUEOUS EXTRACT OF THE ROOTS OF VERNONIA AMYGDALINA DELILE (ASTERACEAE) IN RATS. Patience C. Nwonu , Chukwunwike N.S. Nwonu and Benson C. Aniche. Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria. Department of Pharmacology and Therapeutics, Faculty of Basic and Allied Medical Sciences, College of Health Sciences, Benue State University, P.M.B. 102119, Makurdi, Nigeria. 5, Akpo Street Housing Estate, Feggae, Onitsha, Anambra State, Nigeria
Highlights
Conflicting scientific reports have trailed the hepatotoxicity of the roots of Vernonia amygdalina in animal studies
Vernonia amygdalina Del. (Asteraceae) is a small shrub which is native to the tropical Africa, and typically grows to a height of 2-5 m (Luke et al, 2013)
Mature adult female albino rats were used for the study, which were randomized into test and control groups, with each group consisting of three (3) rats
Summary
Conflicting scientific reports have trailed the hepatotoxicity of the roots of Vernonia amygdalina in animal studies. Hepatotoxicity, albino rats, biochemical markers and retro-orbital bleeding transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and bilirubin (BIL) using graded doses (100, 500, 1000, 1500 mg/kg, p.o.) of the extract demonstrated a significant (P < 0.05) and dose dependent increase in these biochemical markers.
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