INTERACTION BETWEEN CHLOROQUINE SULPHATE AND COCONUT FRUIT WATER IN ADULT MALE RABBITS.

Patiencec Nwonu,Reginaldo Obidike,Chukwunwikens Nwonu

doi:10.21474/ijar01/4336

Abstract

31May 2017 INTERACTION BETWEEN CHLOROQUINE SULPHATE AND COCONUT FRUIT WATER IN ADULT MALE RABBITS. Patience C. Nwonu , Reginald O. Obidike and Chukwunwike N. S. Nwonu. Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria. Department of Pharmacology and Therapeutics, Faculty of Basic and Allied Medical Sciences, College of Health Sciences, Benue State University, P.M.B. 102119, Makurdi, Nigeria. Lecturer, Department of Pharmacology and Therapeutics, Faculty of Basic and Allied Medical Sciences, College of Health Sciences, Benue State University, P.M.B. 102119, Makurdi, Nigeria.

Highlights

The result of the experiment demonstrated a significant decrease in the mean plasma concentration, peak serum concentration and the volume of distribution in the test group
There was no significant difference in the time to peak plasma concentration in the test and control groups, but there was a significant decrease in the biological half-life of chloroquine sulphate in the test group
The mean serum concentration of chloroquine sulphate in the test group was decreased by 53.89 mg% relative to the control group, while the maximum serum concentration of chloroquine sulphate in the test group was decreased by 31.67 mg%

Summary

RESEARCH ARTICLE

INTERACTION BETWEEN CHLOROQUINE SULPHATE AND COCONUT FRUIT WATER IN ADULT MALE RABBITS. 1. Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria. 2. Department of Pharmacology and Therapeutics, Faculty of Basic and Allied Medical Sciences, College of Health Sciences, Benue State University, P.M.B. 102119, Makurdi, Nigeria. 3. Lecturer, Department of Pharmacology and Therapeutics, Faculty of Basic and Allied Medical Sciences, College of Health Sciences, Benue State University, P.M.B. 102119, Makurdi, Nigeria

Inconsistent scientific reports have trailed the use of coconut fruit water

Findings

Chloroquine sulphate alone