Abstract
Background and Aims: Melanocortins, consisting of melanocyte stimulating hormones (α-, β- and γ-MSH) and adrenocorticotropic hormone, mediate their functions through five different melanocortin receptors named from MC1-R to MC5-R. MC1-R is known to be an integral regulator of skin pigmentation and immune responses. Studies conducted in our research group have revealed that MC1-R deficiency in mice disturbs cholesterol and glucose homeostasis through a yet unknown mechanism. The aim of this project was to determine the role of MC1-R in hepatic lipid metabolism.
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