Abstract
Hypernatremia as a cause of acute neurological disorder is being recognized with increasing frequency.1-11Common clinical and metabolic features in infants with fatal outcome were described in the previous paper.12At autopsy, extensive venous occlusion and subarachnoid, subdural, and intracerebral bleeding were prominent findings. Mechanisms for production of these vascular changes and their relative importance in the clinical picture were not clear. It was not known, for example, to what degree hemorrhagic encephalopathy was an integral manifestation of the underlying metabolic disturbance, or whether these vascular lesions merely represented nonspecific, secondary results of transiently disturbed intracranial-pressure relationships. Hyperosmolarity, of order of magnitude similar to that encountered in patients (375-400 mOsm/L.), produces comparable clinical alterations in experimental animals.13,14Within 30 minutes after intraperitoneal injection of hypertonic solutions, cats develop marked tremor, ataxia, muscle twitching, stupor, and occasional convulsions. One cat in three dies within a few hours. In
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
