Abstract
In a previous communication11the results of a study of electroencephalographic (EEG) activation in 37 normal subjects by the use of inhalation of a mixture of 7% oxygen and 93% nitrogen were presented. In this paper the results of the test in 26 subjects suffering from various types of epilepsy will be reported. In all subjects the arterial oxygen saturation and alveolar carbon dioxide concentration (CO2) were continuously recorded with the EEG, and the effects of hypoxia were compared with other activation procedures, such as hyperventilation, breath holding, and, in some subjects, ocular compression.3The effects of breathing 7% CO2and oxygen mixtures, of breathing 100% oxygen, and of intravenous injection of sodium bicarbonate on induced seizure discharges were also evaluated. Before we proceed with a detailed account of the methods and results of the present study, the history of the use of hyperventilation and
Published Version
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