Abstract
Amosulalol 40 to 60 mg was orally administered for approximately 3 months to 14 patients with mild to moderate essential hypertension to investigate the drug's hemodynamic effects. Eight patients who responded well to the therapy showed an increase in cardiac output and stroke volume and a decrease in total peripheral resistance and volume elasticity, but no changes in heart rate. These hemodynamic effects of amosulalol noticeably differed from those of propranolol. The important hemodynamic features of amosulalol include decreased total peripheral resistance and suppression of reflex tachycardia; these effects result from the drug's selective alpha 1-blocking and beta-blocking activity. From a hemodynamic aspect, amosulalol is preferable to a beta-blocker in the treatment of hypertension.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call