Abstract
Background: This study was conducted to evaluate certain haemato-biochemical changes during Xylazine-Ketamine (X-K) and Xylazine-Thiopentone (X-T) anesthesia in dogs. Methods: For this, six dogs of 18 to 25 kg BW were selected and divided into two groups: Group I (X-K) and Group II (X-T). Atropine sulfate @ 0.05 mg/kg BW (IM) was used for premedication in both groups. Dogs in Group I (n=3) were anaesthetized with Xylazine HCl @ 1.1 mg/kg BW (IM) and Ketamine HCl @ 5.5 mg/kg BW (IM), whereas Xylazine HCl @ 1.1mg/kg BW (IM) and Thiopentone sodium @ 20 mg/kg BW (IV) were used for anesthesia in Group II (n=3). In both groups, peripheral blood samples were collected from the dogs before induction of anesthetic agents (control) and thereafter on 10, 20, 30, and 40 minutes of post-induction and again after complete recovery from anesthesia to evaluate hematological changes in Total Erythrocyte Count (TEC), Haemoglobin (Hb) and Packed Cell Volume (PCV). In addition, serum biochemical changes in Total Serum Protein (TSP), Blood Urea Nitrogen (BUN), Creatinine, Sodium (Na), Potassium (K), and Chloride (Cl) were also assessed in both groups. Results: TEC, Hb, and PCV were altered significantly (P<0.05) in most of the cases, TSP was decreased significantly (P<0.05) but BUN was increased significantly (P<0.05), and creatinine was also increased in both groups during the experiment. There were mild alterations in Na, K, and Cl values after induction, and found near to the baseline (control) after recovery. Conclusions: These findings ascertained that the anesthetic combinations of X-K and X-T assert some definite haemato-biochemical changes in dogs which should be carefully judged by the veterinarians during surgical interventions to avoid anesthesia-related risks and complications.
Highlights
Various combinations of anesthetic agents are often used for general anesthesia in dogs (Anandmay et al, 2016) during major and minor surgical approaches (Cima et al, 2016) for fracture, tumor, spaying, castration, gastrotomy, cystotomy, enterectomy (Munif et al, 2020) and so on
This research work was carried out from February to November 2018 in the Veterinary Teaching Hospital of Bangladesh Agricultural University, Mymensingh-2202 to find the effects of Xylazine-Ketamine and Xylazine-Thiopentone anesthesia on some hematological and biochemical indices in dogs premedicated with Atropine sulfate
In Group I (n=3), dogs were anaesthetized with Xylazine-Ketamine combination, whereas Xylazine-Thiopentone combination were used to anaesthetize the dogs in Group II (n=3)
Summary
Various combinations of anesthetic agents are often used for general anesthesia in dogs (Anandmay et al, 2016) during major and minor surgical approaches (Cima et al, 2016) for fracture, tumor, spaying, castration, gastrotomy, cystotomy, enterectomy (Munif et al, 2020) and so on. Thiopental sodium, a short acting barbiturate for animals (Lumb and Jones, 1984; Hall et al, 2000), is one the most chosen anesthetic drugs by the veterinary surgeons (Muhammad et al, 2009) for its effective hypnotic properties that causes depression of the central nervous system (Saini et al, 2017). It is used slowly and intravenously during anesthetic induction for various surgical approaches in dogs (McClune et al, 1992).
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