Abstract
Aims: To develop a tumor-targeted chemo-photothermal nanomedicine through the functionalization of acridine orange (AO)-loaded gold-core mesoporoussilica shell (AuMSS)nanorods withpolyethylenimine (PEI) and hyaluronic acid (HA). Methods: Functionalization of theAuMSS nanorodswas achieved through the chemical linkage of PEI followed by electrostatic adsorption of HA. Results: HA functionalization improved AuMSS'cytocompatibility by decreasing blood hemolysis, and PEI-HAinclusion promoted a controlled and sustained AO release. In vitro assays revealed that HA functionalization increased the internalization ofnanoparticles byhuman negroid cervix epithelioid carcinoma cancer (HeLa)cells, and the combinatorial treatment mediated by AuMSS/PEI/HA_AO nanorods presented an enhanced effect, with >95% ofcellular death. Conclusion: AuMSS/PEI/HA_AO formulations can act as tumor-targeted chemo-photothermal nanomedicines for thecombinatorialtherapy ofcervical cancer.
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