Guava Seeds Derived Phytochemicals against Dysentery

Barsha Nayak,Bibhu Prasad Mishra,Dipankar Bhattacharya,Lopita Mishra,Mukundjee Pandey

doi:10.9734/jpri/2020/v32i730522

Abstract

Phytochemicals are the secondary metabolites that are known as nonnutritive but extremely beneficial for the defensive system for the organism. These phytochemicals can be obtained from all the plants and they play a major role in curing differnt diseases. The extract of the guava seed contains various phytochemicals that can cure the disease like dysentery, caused by the protozoa parasite, namely Entamoeba histolytica. “Biovia Discovery Studio” was used for the molecular docking process. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that Heptadecanoic acid can effectively deactivate the alcohol dehydrogenase enzyme further inhibiting the biological process of the causative organism.

Highlights

Nature has been an abundant source of medicinal agents for thousands of years and an impressive number of modern drugs have been derived from natural plant resources or their derivatives [1]
This study focuses on the identification of the phytochemical of Guava seeds responsible for curing dysentery caused by a protozoan Entamoeba histolytica
-CDOCKER energy was calculated based on the internal ligand strain energy and receptor-ligand interaction energy. -CDOCKER interaction signifies the energy of the non-bonded interaction that exists between the protein and the ligand

Summary

Introduction

Nature has been an abundant source of medicinal agents for thousands of years and an impressive number of modern drugs have been derived from natural plant resources or their derivatives [1]. Mishra et al.; JPRI, 32(7): 124-127, 2020; Article no.JPRI.57278 definite physiological actions on the human body. These substances are called phytochemicals [2]. These phytochemicals can be extracted from any part of the plant and they have shown to have key role in human health science [3]. Guava seeds are known to contain “phytochemicals like Arachidic acid, Heptadecanoic acid, Lauric acid, Linoleic acid, Oleic acid, Palmitic acid, pectin, Phytic acid, Stearic acid” [4]. This study focuses on the identification of the phytochemical of Guava seeds responsible for curing dysentery caused by a protozoan Entamoeba histolytica

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Conclusion