Budleja asiatica Derived Phytochemicals against Eye Disease

Bhakti Bhusan Das,Dipankar Bhattacharyay,Mukundjee Pandey,Sarthak Siddhant Mishra,Sasmita Patra

doi:10.9734/jpri/2020/v32i730521

Abstract

The secondary metabolites in the plants are the reason for curing various diseases. And the phytochemicals present in Budleja asiatica plant extract can cure Eye disease which is caused by Haemophilus influenzae is a facultatively anaerobic, gram-negative pathogenic bacteria. For analysis of ligand-protein interaction, the molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that lignoceric acid can effectively deactivate Aspararte semialdehyde dehydrogenase enzyme which is important macromolecule for the regulation of amino acid biosynthesis resulting in interrupting the life cycle of the microorganism.

Highlights

We focused on the Aspararte semialdehyde dehydrogenase and oxidoreductase which are known to regulate the biosynthesis of amino acid
It was previously known that Budleja asiatica plant has medicinal action against Eye disease
Eye disease is caused by Haemophilus influenzae

Summary

INTRODUCTION

But natural remedies can be this era, people rely on herbal medicine due to used for curing both physical and mental the various medicinal properties like antihealth [1]. Budleja asiatica is tender deciduous shrub belongs to the family Scrophulariaceae family, found in most part of India This plant extract have various medicinal properties like antibacterial, anti-fungal, antihepatotoxic, antioxidant, hypotensive, anti-malaria, antiinflammation. We focused on the Aspararte semialdehyde dehydrogenase and oxidoreductase which are known to regulate the biosynthesis of amino acid It participate in the early branch point in the metabolic pathway forming lysine, methionine, leucine and isoleucine from asparatate and this pathway produces diaminopimelate which plays a important role in bacterial cell wall formation

List of phytochemicals

Enzyme found in Haemophilus influenzae

Molecular docking

AND DISCUSSION

CONCLUSIONS