Abstract
Adeno-associated satellite viruses need participation of a helper adenovirus for their complete replication cycle in susceptible cells. Omission of exogenous arginine from the growth environment renders the adenovirus helper incapable of complete maturation. However, even in the absence of adenovirus particles, viable satellite virus can be isolated from the system. These particles, although originally infectious, lose infectivity rapidly and are less stable morphologically than satellite viruses produced under standard nutritional conditions. Particles are found in the nucleus and in the cytoplasm indicating that transport of viral components is not inhibited. In addition, type 4 satellite virus particles harvested from arginine-deficient growth conditions lack the hemagglutinin normally associated with the mature type 4 virion.
Published Version
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