Abstract
The growth-inhibitory activity of Thymus tosevii oil was evaluated using the agar diffusion method against 7 intestinal bacteria. The essential oil of T. tosevii exhibited potent growth-inhibitory activities against harmful intestinal bacteria. The growth-inhibitory activities of 5 oil components were evaluated against 7 intestinal bacteria to identify the active compound in T. tosevii oil. The growth-inhibitory activities of T. tosevii oil against harmful intestinal bacteria were attributed to myrtanol. Study of the structure-activity relationships between myrtanol structural analogues and antimicrobial activities revealed that (−)-cis-myrtanol, (+)-trans-myrtanol, and (−)-trans-myrtanol exhibited potent antimicrobial activities against harmful intestinal bacteria. Tetracycline was more active than the myrtanol analogues against intestinal bacteria as tetracycline inhibited growth of both beneficial and harmful intestinal bacteria. Some myrtanol analogues exerted selective growth inhibitory activities against harmful intestinal bacteria without adverse effects against beneficial intestinal bacteria.
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