Abstract
The selection of silver metal for the biosynthesis of nanoparticles is a great choice as it exhibits a wide range of applications. Boerhavia Erecta is an extraordinary plant species thatis useful and unique because of its physical characteristics and genetic composition. The current study reported the synthesis of silver nanoparticles by using B. Erecta leaf extract and spectral characterized and studied their properties to target ovarian cancer by antitumorigenic activity. Green synthesized Boerhavia Erecta silver nanoparticles (Be-AgNPs) exhibit the Surface Plasmon resonance phenomenon at 446 nm. The particle size of Be-AgNPs was found to be 15.9 ± 1 nm by particle size analyzer technique. The zeta potential of the biosynthesized Be-AgNPs found to be -36.9 mV, which is a high negative charge indicating its stability and polydispersed nature. The FT-IR results confirmed the presence of secondary metabolites and proteins around the green synthesized Be-AgNPs, which are responsible for the reduction and stability of the nanoparticles. The antioxidant study confirmed the high reflection of reduction property of oxygen free radicals, and the antibacterial activity showed moderate activity against both gram-positive and gram-negative microorganisms when compared with standard antibiotics by disc diffusion assay. Anticancer studies reveal that the biosynthesized Be-AgNPs were very effective and cytotoxic to ovarian cancer PA-1 cell line at the concentration of 25 µg/ml confirmed by performing MTT assay. It is concluded that the eco-friendly biosynthesized Be-AgNPs show evidence of a high range of anticancer properties against ovarian cancer PA-1 cell lines, antioxidant and moderate antibacterial activity. Hence the biosynthesized Be-AgNPs can be good source antioxidants, and anticancer agent’s in future therapeutic applications.
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