Abstract
Present work produces an excellent green route for the synthesis of Schiff bases derived from 2, 6 diamino pyridine, by using lemon juice as the catalyst. This method is experimentally simple, quick, clean and high yielding. Purity and yield of the reaction is increased by using lemon juice there by avoided the traditional dehydrating agents like glacial acetic acid. This method was successfully extended for the synthesis of different Schiff bases derived from 2,6 diamino pyridine like N,N´-bis(2-hydroxy-1-napthalene)-2,6-pyridiamine, N,N´-bis(2-methoxy-1-napthalene)-2,6-pyridiamine and N,N´-bis (naphthalene)- 2,6-pyridiamine. These compounds were prepared by using catalytic amount of lemon juice, and found more economical, safe, neat and eco friendly than using other commercially available dehydrating agents.The synthesized compounds were characterized by FT-IR, 1HNMR spectroscopy, CHN analysis and mass. Compounds are screened for their antifungal activity against Aspergillusniger and M.fufur while antibacterial activity was checked against E.coli, Klebsiella, Bacillus cereus and Staphylococcus aureus. Hydroxyl derivative of the compound was showing significant anti bacterial activity against all selected bacteria. Klebsiella was showing a considerable inhibition compared to standard Tetracycline.
Highlights
The search for new antibacterial agents to treat the bacterial infection has become an unavoidable area of scientific research due to the increasing incidence of multi resistant bacterial infections in the community as well as the development of bacterial resistance to available antibiotics
A condensed product of aromatic amine and aldehydes have been known to posses wide range of applications like anti bacterial anti fungal, anti tumor, analgesic, anti inflammatory, anti toxic,anti HIV, anti cancer as well as other biological activities [1]
Poly cyclic Schiff bases derived from 2,6 diamino pyridine, which contains methoxy, and hydroxyl substituent have been preferentially synthesized through green route and compared the anti microbial activity with a least substituted derivative of the same
Summary
The search for new antibacterial agents to treat the bacterial infection has become an unavoidable area of scientific research due to the increasing incidence of multi resistant bacterial infections in the community as well as the development of bacterial resistance to available antibiotics. In the present work we have synthesized Schiff bases of substituted napthaldehyde and aromatic amines by employing Lemon juice as green catalyst. P(a):To a stirring solution of 2-hydroxy-1-naphthaldehyde (1.5g, 9.1mmol) lemon juice 1.0 ml was added and continued the stirring for 2-3minute. P(b) : To a stirring solution of 2-Methoxy-1-naphthaldehyde (1.7g, 9.1mmol) lemon juice 1.0 ml was added and continued the stirring for 2-3minute. P(c): To a stirring solution of 1-naphthaldehyde (1.4g, 9.1mmol) lemon juice 1.0 ml was added and continued the stirring for 2-3minute. The reaction mixture was cooled to room temperature and the resulting precipitate was filtered and washed with cold methanol. Completion of reaction was confirmed by treating the product with Schiff reagent, were the absence magenta colour indicated the absence of aldehyde. After incubation the zone of inhibition formed on each plates were noted down [15, 16, 17]
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