Abstract
Background. The association of obesity with the odds of diagnosed prostate cancer (DPC) is inconclusive. Whether grade 2 or grade 3 obesity is associated with increased odds of DPC has not been investigated. Design and Methods. Cross-sectional data of 7,974 subjects aged ≥40 years were collected from the National Health and Nutrition Examination Survey 2001–2010. Odds ratios (ORs) of DPC associated with grade 2 or grade 3 obesity were estimated by conducting weighted logistic regression models. Results. The unadjusted rates of DPC did not differ significantly over grades of BMI (P=0.7044). After adjustment for different groups of potential confounding factors, grade 2 or grade 3 obesity was not significantly associated with the odds of DPC with ORs changing from 0.62 to 0.69 for grade 2 obesity and from 0.81 to 1.09 for grade 3 obesity. Moreover, morbid obesity (grade 2 and 3 obesity combined) was not linked to the odds of DPC. Conclusion. Grade 2 or grade 3 obesity was not associated with the odds of DPC. Whether they are associated with a substantially increased risk of high-grade DPC needs to be further investigated as accumulating evidence has shown that obesity increases the risk of high-grade disease.
Highlights
Prostate cancer is the most commonly diagnosed non-skin cancer and the second leading cause of cancer death in American men [1, 2]
Among men grouped by selected factors, the overweight rate was highest in each group from 34.4% in men with other race to 48.3% in Hispanics
We examined the association among grade 2 obesity, grade 3 obesity, and the odds of diagnosed prostate cancer (DPC) in men aged 40 years or older using the data from NHANES 2001– 2010
Summary
Prostate cancer is the most commonly diagnosed non-skin cancer and the second leading cause of cancer death in American men [1, 2]. Despite high comorbidities associated with prostate cancer, most men diagnosed with prostate cancer have survived from it. While we do not know exactly what causes prostate cancer, we do know that certain risk factors are linked to the disease. Identification of risk factors of prostate cancer would be crucial for prevention and control of the disease. The association of obesity with the odds of diagnosed prostate cancer (DPC) is inconclusive. Whether grade 2 or grade 3 obesity is associated with increased odds of DPC has not been investigated. After adjustment for different groups of potential confounding factors, grade 2 or grade 3 obesity was not significantly associated with the odds of DPC with ORs changing from 0.62 to 0.69 for grade 2 obesity and from 0.81 to 1.09 for grade 3 obesity. Whether they are associated with a substantially increased risk of high-grade DPC needs to be further investigated as accumulating evidence has shown that obesity increases the risk of high-grade disease
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