Abstract
IntroductionRecently, various nanoparticles containing medicinal plants have been specifically designed to deliver anticancer drugs and nucleic acids such as DNA and RNA to cancer cells and as a result, they open up new avenues in cancer treatment strategies. In this study, gold nanoparticles were synthesized in aqueous medium using Nigella damascena extract as stabilizing and reducing agents. Material and methodsThe synthesized nanoparticles (AuNPs) were characterized using different techniques including UV-Vis. and FT-IR spectroscopy, and Transmission electron microscopy (TEM). TEM images exhibited a uniform spherical morphology in size of 21.64 nm for the biosynthesized nanoparticles. In the cellular and molecular part of the recent study, the treated cells with AuNPs were assessed by MTT assay for 48h about the cytotoxicity and anti-human ovarian cancer properties on normal (HUVEC) and ovarian cancer cell lines i.e. PA-1, Caov-3, SW 626, and SK-OV-3. ResultsThe viability of malignant ovarian cell line reduced dose-dependently in the presence of AuNPs. The IC50 of AuNPs were 232, 204, 193, and 288 µg/mL against PA-1, Caov-3, SW 626, and SK-OV-3 cell lines, respectively. In the antioxidant test, the IC50 of AuNPs and BHT against DPPH free radicals were 151 and 142 µg/mL, respectively. ConclusionsAfter clinical study, gold nanoparticles containing Nigella damascena leaf aqueous extract may be used to formulate a new chemotherapeutic drug or supplement to treat the several types of human ovarian cancer.
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