Glutamatergic input from specific sources influences the nucleus accumbens-ventral pallidum information flow

Abstract

Event Abstract Back to Event Glutamatergic input from specific sources influences the nucleus accumbens-ventral pallidum information flow E. Papp1*, Z. Borhegyi2, R. Tomioka2, K. S. Rockland3, I. Mody4 and T. F. Freund1 1 Hungarian Academy of Sciences, Institute of Experimental Medicine, Hungary 2 Medical University of Vienna, Center for Brain Research, Austria 3 MIT, Picower Inst. Learning and Memory, RIKEN-MIT Center for Neural Circuit Genetics, United States 4 University of California, Departments of Neurology and Physiology, United States The nucleus accumbens (NAc) is positioned to integrate signals originating from limbic and cortical areas and to modulate reward-related motor output of various goal-directed behaviours. The major target of the NAc GABAergic output neurons is the ventral pallidum (VP). VP is part of the reward circuit, and controls the ascending mesolimbic dopamine system, as well as the motor output structures and the brainstem. The excitatory inputs governing this system converge in the NAc from the prefrontal cortex (PFC), ventral hippocampus (vHC), paraventricular thalamic nucleus (PVT) and basolateral nucleus of the amygdala (BLA). It is unclear which if any of these afferents innervate the medium spiny neurons of the NAc, that project to the VP. To identify the source of glutamatergic afferents that innervate neurons projecting to the VP, a dual-labelling method was used: Phaseolus vulgaris leucoagglutinin for anterograde and EGFP-encoded adenovirus for retrograde tract-tracing. Within the NAc, anterogradely labelled BLA terminals formed asymmetric synapses on dendritic spines that belonged to medium spiny neurons retrogradely labelled from the VP. PVT terminals also formed synapses on dendritic spines of NAc neurons projecting to the VP. However, dendrites and dendritic spines retrogradely labelled from VP received no direct synaptic contacts from afferents originating from mPFC and vHC in the present material, despite the large number of fibres labelled by the anterograde tracer injections. These findings represent the first experimental evidence for a selective glutamatergic innervation of NAc neurons projecting to the VP. Keywords: Neurophysiology, Neuroscience Conference: 13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011. Presentation Type: Abstract Topic: Neurophysiology Citation: Papp E, Borhegyi Z, Tomioka R, Rockland KS, Mody I and Freund TF (2011). Glutamatergic input from specific sources influences the nucleus accumbens-ventral pallidum information flow. Front. Neurosci. Conference Abstract: 13th Conference of the Hungarian Neuroscience Society (MITT). doi: 10.3389/conf.fnins.2011.84.00015 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 03 Mar 2011; Published Online: 23 Mar 2011. * Correspondence: Dr. E. Papp, Hungarian Academy of Sciences, Institute of Experimental Medicine, Budapest, Hungary, papp.edit@koki.hu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers E. Papp Z. Borhegyi R. Tomioka K. S Rockland I. Mody T. F Freund Google E. Papp Z. Borhegyi R. Tomioka K. S Rockland I. Mody T. F Freund Google Scholar E. Papp Z. Borhegyi R. Tomioka K. S Rockland I. Mody T. F Freund PubMed E. Papp Z. Borhegyi R. Tomioka K. S Rockland I. Mody T. F Freund Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.