Abstract
Gestational pemphigoid (GP) is a rare autoimmune blistering disorder that typically occurs in the second or third trimester of pregnancy. Characterized by pruritic, tense blisters primarily affecting the abdomen and extremities, GP can lead to significant discomfort and potential complications for both the mother and fetus. The condition is caused by the production of autoantibodies against basement membrane proteins, resulting in subepithelial blister formation. Differential diagnoses include other pregnancy-related dermatoses, such as pruritic urticarial papules and plaques of pregnancy (PUPPP) and drug-induced bullous eruptions. Histopathological findings typically reveal subepidermal vesicles and lympho-eosinophilic infiltrates, although direct immunofluorescence may be negative in some cases. Management primarily involves symptomatic treatment with corticosteroids and antihistamines, leading to favorable outcomes for most patients. This review highlights the clinical features, differential diagnoses, and management strategies for gestational pemphigoid, emphasizing the importance of early recognition and intervention to ensure maternal and fetal health
Published Version
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