Abstract
In 61 type 2 diabetic patients it was defined single nucleotide polymorphism +276 G > T (rs1501299 ) in adiponectin gene and atherogenic potential dynamics (hormonal and metabolic parameters of insulin resistance, a pro-inflammatory state, oxidative status, adipokines) after daily administration for 12 weeks of omega-3 polyunsaturated fatty acids (Omacor) with the constant pattern of antidiabetic therapy. After the treatment, in all the surveyed it was revealed reduction of insulin resistance, while a significant increase in the levels of total adiponectin, total erythrocyte glutathione, as well as reduced levels of circulating insulin and osteoprotegerin were observed only in carriers of GG-genotype. These results suggest that genetic variations in the adiponectin gene can affect the therapeutic efficacy of omega-3 fatty acids, namely, to reduce the pattern of cardiovascular risk factors in type 2 diabetic patients in a Ukrainian population.
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