Abstract
forms of aldehyde dehydrogenase in liver, and the mitochondrial form is the one principally responsible for acetaldehyde oxidation. This enzyme form is inactive in about 50% of Orientals. Ethanol consumption in these individuals results in markedly elevated blood acetaldehyde levels and the alcohol-flush reaction. Preliminary data from Japan indicate that the genetic absence of mitochondrial aldehyde dehydrogenase is a deterrent or negative risk factor for heavy drinking and alcoholism.
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