Abstract
Activity of brain and liver aldehyde dehydrogenase (ALDH) was measured in male Wistar rats given free access to ethanol and water for 50 days. Brain ALDH activity was better correlated with levels of absolute ethanol intake than liver ALDH, but the magnitude of the relations between enzyme activity and ethanol consumption varied depending on whether animals were regulating their ethanol consumption across different ethanol concentrations: brain and liver ALDH were better correlated with ethanol intake in regulating animals. By contrast, brain ALDH was relatively more important than liver ALDH in predicting ethanol consumption in non-regulating animals. The results suggest that brain and liver ALDH may mediate ethanol consumption in rats by regulating some aspects of the dose-effect relations between acetaldehyde and ethanol.
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