Abstract
Potassium channels form one of the most ubiquitous classes of proteins and are found across all forms of life. Permeation of ions through potassium channels is controlled in different ways, most notably at the lower gate and at the selectivity filter. Here, we focus on the MthK channel, an archaeal calcium-gated potassium channel that has seen wide use as a model system. Particularly, binding of Ca2+ ions opens full-length MthK, possibly also triggering the allosteric coupling between the filter and the gate. To understand the gating behavior in more detail, we apply molecular dynamics (MD) simulations, with and without applied voltage, combined with essential dynamics sampling. This is enabled by the recent availability of both closed and open conformations.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
