Abstract
Strategies to evaluate antioxidant and cytotoxic activity of pet ether extract of Artocarpus chama Buch. seedTaksim Ahmed, Mohammad Nasir Uddin, Md. Kamal Hossain, Md. Imamul Islam, Nizam Uddin, Md. Ehsanul Haque Mazumder
Highlights
Most of the drugs from plants which have become important in modern medicine had a folklore origin and are traditionally used in some systems of medicine (Borgi et al, 2007)
At 250 and 500 mg/kg, Z. lotus L. methanol extract (ZLM) extract did not significantly prevent the formation of gastric lesions induced by HCl/EtOH, whereas, cimetidine and omeprazole treated groups showed a significant reduction (p
On aspirin induced ulcer model, ZLM exhibited at 500 mg/kg a significant reduction in ulcer index (p< 0.05) This gastro-protective effect was less important than that of reference drugs which showed higher inhibitory effects (p< 0.001)
Summary
Most of the drugs from plants which have become important in modern medicine had a folklore origin and are traditionally used in some systems of medicine (Borgi et al, 2007). We aimed to evaluate the anti-ulcer properties of Z. lotus (fruits) methanol extract (ZLM) in various experimental models, as well as its anti-Helicobacter pylori and antiscavenging properties. Up to 500 mg/kg body weight, ZLM produced a nonsignificant inhibition in the acute ulcer induced by HCl/EtOH solution and a significant effect on the aspirin model (46.2 %).
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