Evaluation of Anti Ulcer Activity of Methanolic Leaf Extract of Jacquemontia Caerulea Against Experimentally Induced Ulcers in Wistar Rats

Abstract

Objective: To evaluate the anti-ulcerogenic effect of Jacquemontia caerulea Leaf Methanolic Extract (JCLME) against aspirin, ethanol, cold stress induced and pylorus ligation induced gastric ulcers in Wistar rats. Methods: The methanolic extract of fresh leaves of the plant, Jacquemontia caerulea (Family Convolvulaceae) was prepared and assessed for anti-ulcer effect with different doses and the standard drugs (Risperidone and Amitriptyline respectively) by using aspirin, ethanol, cold stress induced and pylorus ligation methods. Results: JCLME was assessed and compared statistically with the anti-ulcer effects in the control rats which was treated with saline (NaCl, 0.9%). It was found that JCLME at doses of 200 and 400 mg/kg reduced the ulcer index significantly when compared to control group (p< 0.05). It was found that JCLME significantly reduced the free acidity, total acidity and ulcer index (p<0.05) and increased the gastric content when compared with the control group. Hence, the current study shows that the JCLME has potent anti-ulcer, cytoprotective and antisecretory property thereby making it a great ulcero-protective agent.