Abstract
Eight new furan derivatives, irpexins A‒H (1‒8), two new polyketides, irpexins I and J (9 and 10), together with nine known compounds were isolated from the fermentation of Irpex lacteus. The structures and absolute configurations were elucidated on the basis of extensive spectroscopic methods and Mosher ester reaction. All compounds shows no cytotoxicity to human MCF-7 and Hela cancer cell lines at the concentration of 10 μM.Graphic
Highlights
Fungi are important sources of natural products for the discovery of drugs and agricultural chemicals [1,2,3,4,5], which have attracted great attention from pharmaceutical chemists and pharmacologists
Irpex lacteus is a pathogenic wooddecaying fungus belonging to the family Polyporaceae [6]
Its crude polysaccharide fraction has long been used as a traditional Chinese medicine for the treatment of chronic
Summary
Fungi are important sources of natural products for the discovery of drugs and agricultural chemicals [1,2,3,4,5], which have attracted great attention from pharmaceutical chemists and pharmacologists. All new compounds were evaluated for their cytotoxic activities against two human MCF-7 and Hela cell lines
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