Abstract
A facile synthesis for derivatizing fullerenes with diphosphonate groups based on the Bingel reaction has been explored. Five different bisadduct isomers of C60 with tetraethyl methylenediphosphonate, CH2(PO3Et2)2, have been synthesized, separated and characterized by MALDI-TOF mass spectrometry and 31P{1H} and 13C NMR spectroscopy. Hydrolysis of the C60[C(PO3Et2)2]2 isomers generates water-soluble diphosphonic acids, C60[C(PO3H2)2]2 for future in vitro and in vivo studies in which mineralized bone tissue will be selectively targeted.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of the Chemical Society, Perkin Transactions 2
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
