Functional state of the antioxide system in rats with periodontitis against the background of hyper- and hypothyroidism

Abstract

Objective. To investigate the functional state of the antioxidant defense system in rats with periodontitis without concomitant pathology and against hyper- and hypothyroidism.Material and methods. The study involved 48 mature male white rats. The antioxide system was assessed by the activity of superoxide dismutase (SOD), catalase in erythrocytes and periodontal tissues and serum concentration of ceruloplasmin.Results. The decrease in SOD activity in the supernatant of rats’ erythrocyte hemolysate with modeled periodontitis by 16.2% (p <0.05) in rats with periodontitis and hypothyroidism — by 38.3% (p <0.001) was observed. In rats with periodontitis and hypothyroidism, catalase activity decreased by 12.4% (p<0.05) vs control group. In the homogenate of periodontal tissues, changes in the enzyme link of the antioxidant defense system were more intense, especially for SOD. In case of periodontitis ceruloplasmin concentration in serum increased by 57,1% (p <0,001), in rats with periodontitis and hyperthyroidism it significantly decreased by 2.0 times, in animals with periodontitis and hypothyroidism — increased by 22.8% (p<0.05) compared with the control.Conclusion. Experimental periodontitis is accompanied by a marked decrease in the functional activity of antioxidant protection in both the homogenate of periodontal tissues and in the blood. The imbalance of thyroid hormones in different directions deters antioxide system in periodontitis: in case of hyperthyroidism — by reducing the concentration of ceruloplasmin, in case of hypothyroidism — by reducing the activity of superoxide dismutase and catalase.