Functional condition of vascular endothelium in patients with coronary heart disease in combination with non-alcoholic fatty liver disease, depending on weight and influence of statin therapy

Abstract

Aim. 28 Patients have been observed to examine correlation between functional condition of vascular endothelium, and weight in patients with coronary heart disease in combination with non-alcoholic fatty liver disease and also its dynamics under influence of statin therapy.Methods and results. In 20 patients endothelium-dependent vasodilation (EDVD) has been detected based on reactive hyperemia and its dynamics depending on the body mass index under the influence of statin therapy.Conclusion. In patients with ischemic heart disease, obesity and NAFLD first degree expressed positive dynamics on endothelial function (57%) in contrast to patients with overweight (44%) has been revealed during therapy with pitavastatin 2 mg for 8 weeks; besides an increase of hepatic transaminases has not been detected, which means that the abolition of the drug was not required.