FUNCTIONAL ACTIVITY OF THROMBOCYTOSIS HEMOSTASIS SECTION IN EXPERIMENTAL MODELING OF GINGIVITE AND ALVEOLITES

Abstract

The aim of the study was to study the functional activity of platelet hemostasis in the experimental modeling of gingivitis and alveolitis.Materials and methods. The study was carried out on non-linear laboratory white male rats weighing 240.0 ± 30.0 g divided into four groups: experimental gingivitis, alveolitis and two groups of intact control by examination of platelet aggregation, determination of total, free and bound hydroxyproline in the urine, morphological verification of changes in the bone tissue of periodontal rats.Results. Aggregation activity of platelets with a low concentration of inducer ADP in the alveolitis increases the degree and rate of aggregation. High concentrations of ADP do not cause changes in platelet aggregation. Changes in all levels of hydroxyproline in the urine of rats indicate the breakdown of collagen to varying degrees, depending on the pathology.Conclusions. Low concentrations (2.5 μmol / L) of adenosine diphosphate increase the functional activity of platelets. High concentrations (5.0 and 10.0 μmol / L) of adenosine diphosphate do not affect the functional activity of thrombocytes in animals with alveolitis. Changes in all levels of hydroxyproline in urine in rats, found in rats with gingivitis, and a decrease in free hydroxyproline in rats with alveolitis suggest a pronounced deceleration of collagen degradation in gingivitis and the onset of this process in animals with alveolitis.